Wikipedia has a timeline of the most significant and consequential discoveries and inventions in our bipedal and opposable thumb history.
The apogee in human development of course, in my opinion occurred in the 10th millennium BC with the invention of alcoholic beverages in the Fertile Crescent. Low carb alcohol however was not invented until the 7th millennium.
I think one glaring omission from the list is the frisbee without which we would not have ultimate frisbee, the spork of sports.